The mysterious relationship between Parkinson's disease and gout considered through the search for the origin of life.

Abstract

Summary

The surface layer of the earth is mainly occupied by four elements (hydrogen, carbon, nitrogen, oxygen), each of which exists as a single molecule or a compound. Among them, nitrogen occupies 78% of the atmosphere as a single molecule (N₂), but it is not a major constituent element of substances (minerals, plants and animals), and plays a leading role in "metabolism of animals and plants".

Nitrogen compounds are deeply involved in the birth of life and its evolution on the earth, and it is speculated that high molecular weight organic compounds have become more complex and diverse in the order of nitrogen → urea → amino acids → uric acid → nucleic acids. Then, when the structural formulas of each molecule were compared, most of the amino acids show the shape immediately before forming an aromatic group having a cyclic structure, whereas the nucleic acid is complicated based on the aromatic group.

On the other hand, active oxygen that accelerates aging is generated in the body of living organisms, shortening its lifespan. One of the powerful antioxidants that decompose this active oxygen is uric acid, and in recent years, it has been found that this uric acid reduces the risk of developing Parkinson's disease and suppresses its progression. In addition, diseases such as Parkinson's disease are often caused by extreme oxidative stress, and as a treatment method, it is recommended to use a combination of drug treatment that suppresses the action of active oxygen and emotional treatment that fosters "joyful emotions".