Allele and genotype frequencies of CYP3A5 in the young Japanese population

Abstract

The goal of this study was to determine the frequencies of allele of CYP3A5 in Japanese young subjects. Genotyping of allele CYP3A5 (*1,*2, *3, *4, *5, and *6) was carried out in 235 young Japanese subjects by polymerase chain reaction (PCR) and DNA sequence. The frequencies of CYP3A5*1, *2, *3, *4, *5 and *6 variant alleles in young Japanese are found at frequencies of 0.157, 0, 0.843, 0, 0 and 0, respectively. It provides evidence that the allele frequencies for CYP3A5 in young Japanese are same from those for adult Japanese population. Our result should contribute to a better understanding of the molecular basis of age differences in drug response, which may help to improve individualization of drug therapy in the Japanese population.