Effects of beraprost and cilostazol treatments on the survival time of stroke-prone spontaneously hypertensive rats

Abstract

Effects of beraprost sodium (BPS) and cilostazol treatments on the life span of stroke-prone spontaneously hypertensive rats (SHRSP) were examined. The treatment with BPS (200 μg/kg/day) significantly prolonged the survival time of the SHRSP. The treatment with cilostazol (200 mg/kg/day) showed a tendency to shorten the survival time of the SHRSP, although the effect was not significant. Histological evaluation revealed that lesion degrees, such as the score of inflammation of arteries in the kidneys of the SHRSP were significantly reduced and ameliorated by the BPS treatment, but not by the cilostazol treatment, although such differences between the BPS and cilostazol treatments were not clear in the brain or heart of the SHRSP. The present study confirmed the differential effects of BPS and cilostazol on the survival time of SHRSP, and such differences might be explained in part by the difference of protective effects on the renal lesion in SHRSP between BPS and cilostazol.